An Effective Treatment for Coronavirus (COVID-19) 3-13-20

Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies

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Originally posted by f2:
An Effective Treatment for Coronavirus (COVID-19) 3-13-20

Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies

Saw this a couple days ago on FNC. As soon as the study’s PI started to relay the positive results, his voice was garbled and they scrambled to get him off the air. Instead the news desk switched to some foolish blonde on the street that just had to speak to a mother and child about their feelings.
So many in the news media and social media are desperate to keep the mass hysteria going. Instead of listening about a double blind, placebo controlled study (albeit a small one but hey who wants to take a 50/50 chance of getting the placebo) for a previously approved drug (one normally prescribed against malaria) that reduced the symptoms and hastened their elimination for 5-cents a day... let’s instead go to the street where we can hear the lamenting of women & children. No better way to demonstrate the bullshit nature of what’s taking place.

For those interested in the pre-clinical study that preceded the human trial:
https://www.nature.com/articles/s41421-020-0156-0

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Originally posted by AllenInWV:

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Originally posted by DLC762:
Thankfully the restaurants/bars in WV are still open.

I've got some bad news for you....

CHARLESTON, W.Va. (AP) — All 50 U.S. states now have confirmed cases of the new coronavirus as West Virginia's governor announced the first positive test in his state on Tuesday evening.
Gov. Jim Justice said the person with the virus is in the state's Eastern Panhandle, a region close to Washington, D.C., though he didn't disclose the county where it was reported.
Justice used a televised address to announce new restrictions, ordering bars, restaurants and casinos to close with the except of carry-out food services. He did not address delivery services.
"This is real and it's really concerning," the governor said.

I’ve been told it’s a nurse in the neighboring county of Jefferson. I can’t wait for the ensuing wave of panic buying... not that it’s not already going on.

I’ll be waiting for that good news, a breakthrough in a vaccine or control.

I see dabbling here & there, as linked above.

I expect those in the know are working around the clock to got ahead of this.

The economy was humming along just GREAT, it would be best to limit the damage.

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Originally posted by Dakor:

quote:

Originally posted by f2:
An Effective Treatment for Coronavirus (COVID-19) 3-13-20

Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies

Saw this a couple days ago on FNC. As soon as the study’s PI started to relay the positive results, his voice was garbled and they scrambled to get him off the air. Instead the news desk switched to some foolish blonde on the street that just had to speak to a mother and child about their feelings.
So many in the news media and social media are desperate to keep the mass hysteria going. Instead of listening about a double blind, placebo controlled study (albeit a small one but hey who wants to take a 50/50 chance of getting the placebo) for a previously approved drug (one normally prescribed against malaria) that reduced the symptoms and hastened their elimination for 5-cents a day... let’s instead go to the street where we can hear the lamenting of women & children. No better way to demonstrate the bullshit nature of what’s taking place.

For those interested in the pre-clinical study that preceded the human trial:
https://www.nature.com/articles/s41421-020-0156-0

Thank you for the links. I appreciate the opportunity to look at the science versus listening to the thoughts of so many partially informed people spouting opinions (I don’t mean the forum, I’m talking about the media).

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Originally posted by gearhounds:
I can’t wait for the ensuing wave of panic buying... not that it’s not already going on.

I drove past the local Kroger's this morning about 6:50 or so. There were about 5 people waiting to go in. May have been more waiting in cars as the lot seemed a little busy for that time. Last time I went in was a week ago? Bought some milk and OJ. Grabbed a pack of TP just because while the shelves weren't bare, they were pretty worked over.

My son went to one yesterday, probably in Teays Valley or Huntington. He said while shelves weren't full, he had no problem getting what he needed. I need to get some water for the office, so I'll be making a foray into one today or tomorrow.

The Honda plant at Marysville is closing for a week starting Monday. There are a lot of other manufacturing facilities in Ohio feeding this plant. We will see what the trickle down is on this.

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Originally posted by r0gue:

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Originally posted by Cookster:
Well, we new that it wouldn’t take long for Philadelphia’s new police chief fresh in from Portland, OR to make her mark and thoroughly fuck things up in Philly, so from the proverbial chapter of “What Could Possibly Go Wrong”, sub-chapter titled “What Were They Thinking”, we have this as reported from The Conservative Treehouse -

Thunderdome 2020 Begins – Philadelphia Police Will Not Arrest for Burglary or Theft Due to Coronavirus…

A misleading headline, as they WILL respond, collect info and IDs and issue paperwork. It would seem just delaying the in person processing. Given how slow the justice system is, I guess this just adds a month or two to the same net effect.

My neighbor is a deputy with the largest county in the Houston metro area and says they’re just issuing paperwork too for non-violent (you go to jail for violent and violence is up) because they’re concerned about Wuhan virus getting into their jails. He’s also concerned shitbags will cross state lines and not show because it’ll be too minor to extradite (he said no problem with other Texas cities sending them back).

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Originally posted by tatortodd:

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Originally posted by r0gue:

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Originally posted by Cookster:
Well, we new that it wouldn’t take long for Philadelphia’s new police chief fresh in from Portland, OR to make her mark and thoroughly fuck things up in Philly, so from the proverbial chapter of “What Could Possibly Go Wrong”, sub-chapter titled “What Were They Thinking”, we have this as reported from The Conservative Treehouse -

Thunderdome 2020 Begins – Philadelphia Police Will Not Arrest for Burglary or Theft Due to Coronavirus…

A misleading headline, as they WILL respond, collect info and IDs and issue paperwork. It would seem just delaying the in person processing. Given how slow the justice system is, I guess this just adds a month or two to the same net effect.

My neighbor is a deputy with the largest county in the Houston metro area and says they’re just issuing paperwork too for non-violent (you go to jail for violent and violence is up) because they’re concerned about Wuhan virus getting into their jails. He’s also concerned shitbags will cross state lines and not show because it’ll be too minor to extradite (he said no problem with other Texas cities sending them back).

Even if it is “violent”, unless they kill somebody, they are being immediately released ROR.

A long article from The Wall Street Journal describing what can happen when hospitals and other medical facilities are overwhelmed with cases that don’t necessarily kill everyone (since that seems to be the criterion some people have to believe a disease is “serious” and worth taking precautions to prevent). A couple of statements of possible significant interest to some of the members here:

“Most are headed to the Papa Giovanni XXIII Hospital, a large, modern medical facility in a prosperous Italian city that has been overwhelmed by the coronavirus disease. There aren’t enough ventilators to intubate all patients with Covid-19 who have severe breathing trouble. The intensive- care unit is taking almost no patients older than 70.”

“The hospital had planned to send severe cases to Bergamo. ‘But we got indications that, if patients are over 65 or 70, they won’t get intubated,’ said Davide Grataroli, one of the hospital doctors. ‘So, we’ve chosen to manage them here as best we can.’”

[Emphasis added.]

LINK

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Italy’s Hospitals Pushed to the Brink As Caseload Soars

BY MARCUS WALKER AND MARK MAREMONT

BERGAMO, Italy—Ambulances here have stopped using sirens. The frequent blaring only adds to local fears. Besides, there are few other vehicles on the road in Italy’s national lockdown.

Most are headed to the Papa Giovanni XXIII Hospital, a large, modern medical facility in a prosperous Italian city that has been overwhelmed by the coronavirus disease. There aren’t enough ventilators to intubate all patients with Covid-19 who have severe breathing trouble. The intensive- care unit is taking almost no patients older than 70.

A normally disused section of the hospital is filled with the critically ill and the hissing sound of oxygen. Patients lie quietly, with worried or exhausted faces, visible to others in the series of half-open rooms. Each focuses on the struggle to breathe. There are patients with airtight oxygen helmets over their heads, like transparent buckets taped at the neck.

“Some of them would have needed intubation in intensive care,” anesthesiologist Pietro Brambillasca said. The rest ought to be better isolated, he said, where they can’t contaminate anyone.

That is no longer possible.

The number of ill has outstripped the hospital’s capacity to provide the best care for all. The coronavirus is devastating Bergamo and pushing a wealthy region with high-tech health care toward a humanitarian disaster, a warning for the U.S. and other developed countries. The city’s experience shows how even advanced economies and state-of the-art hospitals must change social behaviors and prepare defenses ahead of a pandemic upending the rules.

Some U.S. doctors are trying to understand how the coronavirus defeated all efforts so far to contain it in Lombardy, the Italian region that includes Bergamo and Milan. They seek lessons but don’t have much time, as the pandemic, now coming under control in China, takes off throughout the West.

Maurizio Cereda, an intensive- care doctor and anesthesiologist in Philadelphia, recently circulated a list of lessons from Italy to colleagues. Dr. Cereda, now at the Hospital of the University of Pennsylvania, trained in Milan and has been in close touch with Italian colleagues in Bergamo and elsewhere.

Many of the lessons relate to public health, to avoid overwhelming hospitals. “Mild-tomoderate cases should be managed at home, not in the hospital, and with massive deployment of outreach services and telemedicine,” he wrote. Some therapies could be delivered by mobile clinics.

Another lesson: Italian emergency-medical technicians have experienced a high rate of infection, spreading the disease as they travel around the community.

Dr. Cereda warned that smaller hospitals “are unprepared to face the inflow of patients” and are likely to collapse. He suggested admitting the sickest patients to bigger facilities and using dedicated ambulances for suspected coronavirus patients.

Italy’s death toll from the coronavirus hit 2,158 on Monday, up 349 since Sunday. The country is on course to overtake China’s toll within days. Its large elderly population is especially vulnerable to Covid-19, the respiratory disease caused by coronavirus.

About two-thirds of Italy’s dead, 1,420 people, are in Lombardy, the ground zero of Europe’s epidemic. It is where the virus is all the more deadly because hospitals in the worst-hit towns have reached

their limits. Bergamo, in particular, has become Italy’s symbol of an epidemic spinning out of control.

Studying the dire turn of events in Italy has helped U.S. doctors better prepare, said Brendan Carr, chair of emergency medicine for The Mount Sinai Health System, a New York City hospital network.

Dr. Carr said he and other U.S. physicians have had informal calls with Italian doctors in recent weeks. “It’s terrible to hear them talk, but it benefits us to learn from it,” he said. One lesson, he said, is to build capacity for the expected influx of Covid-19 patients before it’s needed. Mount Sinai is clearing out space and creating new ICU beds, he said.

Bergamo shows what happens when things go wrong.

In normal times, the ambulance service at the Papa Giovanni hospital runs like a Swiss clock. Calls to 112, Europe’s equivalent of 911, are answered within 15 to 20 seconds. Ambulances from the hospital’s fleet of more than 200 are dispatched within 60 to 90 seconds. Two helicopters stand by at all times. Patients usually reach an operating room within 30 minutes, said Angelo Giupponi, who runs the emergency response: “We are fast, in peacetime.”

Now, people wait an hour on the phone to report heart attacks, Dr. Giupponi said, because all the lines are busy. Each day, his team fields 2,500 calls and brings 1,500 people to the hospital. “That’s not counting those the first responders visit but tell to stay home and call again if their condition worsens,” he said.

The Papa Giovanni XXIII Hospital, a 950-bed complex that opened in 2012, is among the most advanced in Italy. It treats everything from trauma and heart surgery to organ transplants for children.

More than 400 of the beds are now occupied by confirmed or suspected coronavirus patients. The intensive-care unit has swelled to around 100 patients, most of whom have Covid-19. New cases keep arriving. Three of the hospital’s four top managers are home with the virus.

“Until three weeks ago, we did everything for every patient. Now we have to choose which patients to put in intensive care. This is catastrophic,” said anesthesiologist and intensive-care specialist Mirco Nacoti.

Dr. Nacoti worked for Doctors Without Borders in Haiti, Chad, Kurdistan and Ivory Coast, and he is one of the few medics in Bergamo who has seen epidemics. Yet, those were diseases with vaccines, such as measles and rubella.

He estimated around 60% or more of the population of Bergamo has the virus. “There is an enormous number of asymptomatic people, as well as unknown dead who die in their home and are not tested, not counted,” he said. “The ICU is the tip of an iceberg.”

Hospitals in the U.S. and across Europe must organize in advance, Dr. Nacoti said, and governments need community lockdowns early. “An epidemic doesn’t let you proceed by trial and error,” he said. “Every day you lose, the contagion gets worse.”

Bergamo, a city of about 120,000 northeast of Milan, sits at the heart of one of Italy’s wealthiest regions. Companies nearby make San Pellegrino mineral water, luxury yachts, and brakes for Ferrari.

When Bergamo discovered a clutch of coronavirus cases in its outlying towns around Feb. 22, Dr. Giupponi of the Papa Giovanni hospital emailed Lombardy’s regional health authorities. He urged them to empty out some hos- pitals and use them exclusively for coronavirus cases.

Regional managers at the time were dealing

with an outbreak south of Milan. “We haven’t slept for three days and we do not want to read your bullshit,” Dr. Giupponi recalled their reply.

Since then, Italy’s lockdown has turned Bergamo into a ghost town.

Death notices in the local newspaper, the Bergamo Echo, normally take up just over a page. On Monday, they filled nine pages.

Doctors on a break at the Papa Giovanni swap stories of woe, including the call from an elderly care home reporting suspected virus sufferers who were over 80 years old. The hospital said the elderly residents had to stay put.

“None of us have ever seen such a thing,” trauma surgeon Michele Pisano said. “We’re trained for emergencies, but for earthquakes, not epidemics.” Dr. Pisano has little to do these days: Italy’s lockdown means there are virtually no car crashes, bicycle accidents or broken bones from skiing. He helps out in the coronavirus wards however he can.

In small towns around the province of Bergamo, the pressure on hospitals is worse.

Dr. Nacoti helps at a hospital in San Giovanni Bianco, located in the foothills of the Alps. On Sunday evening, the facility had around 70 corona-virus patients. The hospital, which specializes in outpatient surgery, normally has 20 beds.

Recently arrived patients lay on gurneys, filling the emergency room and a corridor while they wait for beds.

Upstairs, more than 50 patients were administered oxygen through helmets or masks. Some were in critical condition, but the hospital has no intensive-care unit and no ventilators. “We thought seven beds downstairs and seven upstairs would be enough,” senior nurse Fiorella Busi said.

The hospital had planned to send severe cases to Bergamo. “But we got indications that, if patients are over 65 or 70, they won’t get intubated,” said Davide Grataroli, one of the hospital doctors. “So, we’ve chosen to manage them here as best we can.”

Patients know that the lack of intensive-care facilities dooms those not strong enough to survive with only limited help. “They accept it with resignation and no complaints,” said Ms. Busi, the nurse.

“The most devastating part is that they are dying alone,” she said. “Families see the patient for the last time at the emergency room. The next time is at the mortuary.”

Such a lonely death is hard to take, the nurse said: “It’s not our culture. We’re very connected here.”

This message has been edited. Last edited by: sigfreund,

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Originally posted by jljones:

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Originally posted by tatortodd:

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Originally posted by r0gue:

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Originally posted by Cookster:
Well, we new that it wouldn’t take long for Philadelphia’s new police chief fresh in from Portland, OR to make her mark and thoroughly fuck things up in Philly, so from the proverbial chapter of “What Could Possibly Go Wrong”, sub-chapter titled “What Were They Thinking”, we have this as reported from The Conservative Treehouse -

Thunderdome 2020 Begins – Philadelphia Police Will Not Arrest for Burglary or Theft Due to Coronavirus…

A misleading headline, as they WILL respond, collect info and IDs and issue paperwork. It would seem just delaying the in person processing. Given how slow the justice system is, I guess this just adds a month or two to the same net effect.

My neighbor is a deputy with the largest county in the Houston metro area and says they’re just issuing paperwork too for non-violent (you go to jail for violent and violence is up) because they’re concerned about Wuhan virus getting into their jails. He’s also concerned shitbags will cross state lines and not show because it’ll be too minor to extradite (he said no problem with other Texas cities sending them back).

Even if it is “violent”, unless they kill somebody, they are being immediately released ROR.

You could, at a minimum, break a leg or something. Maybe shoot 'em in the foot.

Looks like the Purge starts in Philly!

I bet most police departments are doing this, Philly is just dumb enough to publicize it.

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Now, people wait an hour on the phone to report heart attacks, Dr. Giupponi said, because all the lines are busy.

In some ways, I think this is one of the most important lines in the article.

As I have said before here, if the healthcare system gets overwhelmed with Coronavirus cases, it isn't just coronavirus cases that don't get adequate care.

We just had the biggest earthquake I've ever felt in my 16 years in Park City.

Lung Pao Sicken panic and now an earthquake. And we also woke up to a few inches of snow on the ground. I'm starting to think someone is playing Jumanji.

https://www.deseret.com/utah/2...unity-silicon-slopes

A Utah-based diagnostic testing company says its continuing its pursuit of authorization from the U.S. Food and Drug Administration to issue emergency approval for a COVID-19 test that’s already in use in Europe and could markedly amp up testing capacity in Utah and other areas of the Intermountain West.

The company says it has the resources to produce 50,000 or more of the tests daily from its Salt Lake facility. Each test, according to the company, costs about $10 per patient, delivers results in about 90 minutes and can be processed at most medical labs.

During a community leaders call hosted Monday by Utah tech sector advocacy group Silicon Slopes, Co-Diagnostics communication director Seth Egan said his company has already earned approval from the European Union for its test, which uses a sputum sample to look for evidence of COVID-19, but continues to await action from the FDA under the agency’s expedited emergency use protocol for COVID-19 testing.

“With FDA approval through emergency use authorization we could supply all of the testing needs in Utah and around us easily,” Egan said. “We sit here a little bit amazed that we have a test available in European nations but we can’t sell it as a clinical diagnostic in our own home state.

Sat in on a MS Dept. of Health call yesterday that was available to providers, admins, etc. Interesting perspective of the "testing kits" shortfall.

Even in MS it seem the state and other agencies/firms have plenty of capacity currently to process test.

The interesting discussion was from clinic and hospitals that no longer have supplies to take the test. Essentially a specific nasal swab type plus a bag and packaging for transport. The state agencies aren't in the supply chain for these, the sites can't get their own through normal channels and the only advice was to contact the MEMA to get in line for request from national efforts to distribute these. If that's an issue in a state with as low a population as us, imagine it's widespread.

Hopefully someone out there is making a crapton of these items or all the labs in the country won't help.

They also emphasized the need for folks not to test asymptomatic patients or those without fever over 100.4 as part of effort to prioritize use of supplies. Those tests are also likely to yield false-negatives as well, with same patients showing symptoms and being positive a few days later.

Interesting report. Possibly correct…

“People with Type A blood are significantly more likely to catch coronavirus than those with Type O, Chinese academics have found.

The study in Wuhan - the epicentre of the disease - also found those with Type A blood are more likely to die from COVID-19.

In the general population Type O blood (34%) is more common than A (32%). However, among COVID-19 patients, people with Type O accounted for just 25%, whereas Type A made up 41%.”

https://mol.im/a/8122493

https://www.washingtonpost.com...thats-why-were-here/

Want to know why the U.S. economy is in free fall? Why restaurants and bars are closing, putting millions out of work, and why the airline industry is facing possible bankruptcy? Why schools across the nation are shutting down, leaving students to fall behind and parents without safe places to send their children everyday? Why the stock market is plummeting, wiping out the retirement and college savings of millions of Americans? Why the elderly are isolated in nursing homes and tens of millions who don’t have the option of teleworking have no idea how they will pay their bills?

Answer: Because China is a brutal totalitarian dictatorship.

We are in the midst of a pandemic lockdown today because the Chinese Communist regime cared more about suppressing information than suppressing a virus. Doctors in Wuhan knew in December that the coronavirus was capable of human-to-human transmission because medical workers were getting sick

But as late as Jan. 15, the head of China’s Center for Disease Control and Prevention declared on state television that “the risk of human-to-human transmission is low.”

On Jan. 18, weeks after President Xi Jinping had taken charge of the response, authorities allowed a Lunar New Year banquet to go forward in Wuhan where tens of thousands of families shared food — and then let millions travel out of Wuhan, allowing the disease to spread across the world. It was not until Jan. 23 that the Chinese government enacted a quarantine in Wuhan

If the regime had taken action as soon as human-to-human transmission was detected, it might have contained the virus and prevented a global pandemic. Instead, Chinese officials punished doctors for trying to warn the public and suppressed information that might have saved lives. According to the Times of London, Chinese doctors who had identified the pathogen in early December received a gag order from China’s National Health Commission with instructions to stop tests, destroy samples and suppress the news.

This is what totalitarian regimes do. First, they lie to themselves, and then, they lie to the world. The system creates such fear that people are terrified to report bad news up the chain, causing “authoritarian blindness.” Then, when those at the top finally discover the truth, they try to cover it up — because leaders who abuse their people are less concerned with saving lives than making sure the world does not discover the deadly inefficiency of their system.

Landed at DFW late last night screening was very easy...."have you been to China" " do you have a fever or cough"

Told us to self quarantine and monitor.

No of the locals in Heathrow were wearing masks.

In Kroger now, meat diary dairy products are at 20% stocked...of course no TP

Produce is stocked though....

Buying what we normally eat....but adding 1 or 3 packages.

Going to Costco next....pray for us

From the office of the Governor in California,



http://www.oesnews.com/governo...community-readiness/