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When will the coronavirus arrive in the US? (Disease: COVID-19; Virus: SARS-CoV-2) Login/Join 
Down the Rabbit Hole
Picture of Jupiter
posted Hide Post
quote:
Originally posted by parabellum:
https://twitter.com/backtolife.../1713491156229599629

[FLASH_VIDEO]<iframe id="twitter-widget-1" scrolling="no" src="https://platform.twitter.com/embed/Tweet.html?dnt=true&embedId=twitter-widget-0&frame=false&hideCard=false&hideThread=false&lang=en&theme=&id=1713491156229599629" style="position: static; visibility: visible; width: 550px; height: 657px; display: block; border: medium; background-repeat: no-repeat; background-image: url('https://codejanitor.azurewebsites.net/embeds/bgmessage.png'); background-position: center 20px; background-size: 300px; overflow: hidden;" title="Twitter Tweet"></iframe>[/FLASH_VIDEO]



Another example of why I question everything that comes out of the mouth of the Government, medical establishment, MSM etc..
Some may disagree but I firmly believe this whole Covid pandemic was planned and goes down as one of the greatest conspiracies of all time.


Diligentia, Vis, Celeritas

"People sleep peaceably in their beds at night only because rough men stand ready to do violence on their behalf."
-- George Orwell

 
Posts: 4925 | Location: North Mississippi | Registered: August 09, 2002Reply With QuoteReport This Post
Member
posted Hide Post
Related info is coming out.

"Over the last two years we have all watched in horror as the extent of the harm and damage that has been caused by the Covid injections has been revealed, with more and more irrefutable evidence of unnecessary death and disability coming to light on an almost daily basis."

"According to journalist Jennifer Margulis in her report ‘Parents Need to Know: Are Your Children Over-Vaccinated?’, she soberly concludes, “…instead of reevaluating current immunization practices, the conventional medical community either ignores the science done by medical researchers like Classen and Miller or paints them as wild-eyed anti-vaccine extremists. Scientists who prove that popular and profitable pharmaceutical products can cause harm [like Dr. Paul Thomas] risk losing their livelihoods as well as their standing in the scientific community.”
...
"Dr. Paul Thomas recently revealed shocking statistics in his presentation to Vaccine Choice Canada earlier this year. The slides he shared with us were based on his Health Freedom Summit 2022 presentation comparing the incidence of chronic diseases (as opposed to actual death) in all age groups within the vaccinated and unvaccinated populations of the United States. Across the board he showed that those who had managed to avoid childhood vaccines were much healthier and less prone to health degradation."
...

They are:

  • A 400% greater chance of your child suffering a chronic condition before the age of 18, and then being ten times more likely to suffer a chronic condition as an adult

  • A 48% chance of getting heart disease

  • 208 times greater chance of suffering from chronic sinusitis

  • 45 times greater chance of suffering digestive disorders

  • 20 times greater chance of developing ADHD

  • 17 times greater chance of suffering from epilepsy

  • 12 times greater chance of developing autism

  • 11 times greater chance of developing learning disabilities

  • 10.5 times greater chance of getting asthma

  • 9.6 times greater chance of developing speech disorders

  • 7 times greater chance of getting eczema

  • 6 times greater chance of developing a food allergy

  • 5.6 times greater chance of having developmental disabilities

  • A 16.67% chance of getting arthritis in later life

  • A 10% chance of getting diabetes


    Article: The Real Risks of Childhood Vaccines
  •  
    Posts: 2381 | Registered: October 24, 2007Reply With QuoteReport This Post
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    Picture of konata88
    posted Hide Post
    How does one establish a control group(s) to normalize against for these types of statistics? Seems like that would be a challenge.




    "Wrong does not cease to be wrong because the majority share in it." L.Tolstoy
    "A government is just a body of people, usually, notably, ungoverned." Shepherd Book
     
    Posts: 13184 | Location: In the gilded cage | Registered: December 09, 2007Reply With QuoteReport This Post
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    Picture of cparktd
    posted Hide Post
    We got two Pfizer branded Covid test in the mail just the past week.

    Why?

    We didn’t order, want or need them.

    How many millions are still being sent to others?

    Whose pockets are being filled to authorize this and at what cost to taxpayer?

    Mad

    Will this shit EVER end?



    Collecting dust.
     
    Posts: 4203 | Location: Middle Tennessee | Registered: February 07, 2013Reply With QuoteReport This Post
    Peace through
    superior firepower
    Picture of parabellum
    posted Hide Post
    quote:
    Originally posted by cparktd:
    Will this shit EVER end?
    It might end now, what with the bottom dropping out of the money machine and no one falling in line this time around.
     
    Posts: 109769 | Registered: January 20, 2000Reply With QuoteReport This Post
    No More
    Mr. Nice Guy
    posted Hide Post
    quote:
    Originally posted by konata88:
    How does one establish a control group(s) to normalize against for these types of statistics? Seems like that would be a challenge.


    That is a deep rabbit hole.

    The control group for some of the vaccines are the previous version, and those previous versions may never have had a true placebo control group to determine either safety of effectiveness. Thus the new version need only be not as bad as the previous version in order to be approved!

    Some control groups are the injection minus one active ingredient. The correct placebo control would be sterile saline, which should have no side effects. But instead they use the carrier fluid which includes adjuvants and possibly impurities which can themselves be a big problem. Things like mercury and aluminum, which are known neurotoxins. So the placebo might be causing all kinds of nasty problems, which then the active product will have too. So the active product will be no more harmful than the placebo, and deemed safe.

    The more I learn about how pharma products get approved, the more I am determined to avoid them all.
     
    Posts: 9816 | Location: On the mountain off the grid | Registered: February 25, 2002Reply With QuoteReport This Post
    Lawyers, Guns
    and Money
    Picture of chellim1
    posted Hide Post
    Johns Hopkins University professor Dr. Marty Makary, an actual expert, is not a happy camper. He angrily told the House Select Subcommittee on the Coronavirus Pandemic during its first hearing last week that "the greatest perpetrator of misinformation during the pandemic has been the United States government.”

    True. The U.S. Government should have a thirty-day social media timeout for spreading misinformation, to see how it feels.

    CLIP: Spicy excerpt of Dr. Makary testimony to House Covid Committee (2:08).

    https://twitter.com/backtolife...491156229599629?s=20



    Dr. Makary didn’t mince words. A real expert, Dr. Makary accused the government’s public health establishment of lying, of “weaponizing medical research” with manipulated, fraudulent studies. You don’t have to believe me — believe Dr. Makary:

    “We’ve seen something which is unforgivable. And that is the weaponization of medical research itself. The CDC putting out their own shoddy studies — like their own study on natural immunity looking at one state for two months, when they had data for years on all fifty states — why did they only report that one sliver of data? Why did they salami slice that giant database? Because it gave them the result they wanted. Same with masking studies… Public health officials were intellectually dishonest. They lied to the American people. Thank you.”

    Dr. Makary also said that all the public health establishment has achieved was to create a new category of never-vaxxers, who are even scarier than anti-vaxxers. He has a point. I would mark myself down in the “never-vaxxer” category. If experts like Dr. Makary concluded Public Health lied this much about covid vaccines, who knows how much they’ve been lying about every other so-called vaccine?

    https://www.coffeeandcovid.com...ack&utm_medium=email



    "Some things are apparent. Where government moves in, community retreats, civil society disintegrates and our ability to control our own destiny atrophies. The result is: families under siege; war in the streets; unapologetic expropriation of property; the precipitous decline of the rule of law; the rapid rise of corruption; the loss of civility and the triumph of deceit. The result is a debased, debauched culture which finds moral depravity entertaining and virtue contemptible."
    -- Justice Janice Rogers Brown

    "The United States government is the largest criminal enterprise on earth."
    -rduckwor
     
    Posts: 24772 | Location: St. Louis, MO | Registered: April 03, 2009Reply With QuoteReport This Post
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    posted Hide Post
    At least it stayed in this country and stimulated the economy. I guess Biden got pissed he could not send more covid relief money to the Palestinians. Big Grin


    Florida Deputies Charged With Stealing Hundreds of Thousands in COVID-19 Relief Funds

    https://townhall.com/tipsheet/...elief-funds-n2629915

    Seventeen deputies at Florida sheriff’s office were charged with defrauding federal loan programs intended to help businesses struggling during the COVID-19 pandemic, according to The New York Times.

    The deputies of the Broward Sheriff's Office were reportedly charged in separate cases of wire fraud in connection with collecting money from the Paycheck Protection Program and the Economic Injury Disaster Loan.

    Reportedly, Sheriff Gregory Tony of Broward County said that the deputies facing the charges represented “multiple disciplines” within the agency. Eight deputies, including a sergeant, work in law enforcement. Nine, also including a sergeant, are assigned to the department of detention (via The New York Times):

    The Coronavirus Aid, Relief and Economic Security Act was an economic relief package enacted in March 2020, amid the Covid-19 pandemic, to provide emergency help to the millions of Americans struggling financially from its effects. The program included the authorization of hundreds of billions of dollars in forgivable loans to help small businesses stay afloat by helping pay their employees and providing loans for other expenses.

    The employees of the sheriff’s office used the $495,171 they collectively received from those programs “to unjustly enrich themselves,” Mr. Lapointe’s office said.

    “The proceeds of the loans were not to be used to purchase consumer goods, automobiles, personal residences, clothing, jewelry or for cosmetic surgery,” Mr. Lapointe said at the news conference.

    Nonprofit organization The Florida Bulldog first reported on the investigation, which began in November 2021. At that time, the Broward Sheriff’s Office of Inspector General began looking at who in the department had obtained payback-protecting funds, as loan fraud was “an emerging trend within public service agencies.”

    According to Forbes, 15 employees were arrested on federal charges. One current employee and one former employee self-surrendered at the federal courthouse in Fort Lauderdale. Reportedly, the maximum sentence for a wire fraud conviction is 20 years in prison. The maximum sentence for conspiracy to commit wire fraud is five years in prison.


    _________________________
    "Sometimes I wonder whether the world is being run by smart people who are putting us on or by imbeciles who really mean it."
    Mark Twain
     
    Posts: 13380 | Registered: January 17, 2011Reply With QuoteReport This Post
    His diet consists of black
    coffee, and sarcasm.
    Picture of egregore
    posted Hide Post
    quote:
    The deputies of the Broward Sheriff's Office

    Why does that sound familiar? Wasn't this the sheriff's dept. that hid behind trees while that school shooter was running amok inside? And the county that always "finds" loose boxes of ballots whose votes always favor the Democrat?
     
    Posts: 28951 | Location: Johnson City, TN | Registered: April 28, 2012Reply With QuoteReport This Post
    Partial dichotomy
    posted Hide Post
    https://www.theepochtimes.com/...9i1UZAfDZdGPOASJQ%3D

    [PREMIERING 9PM ET] The Truth About COVID Hospital Protocols: Stella Paul

    Oct-17-2023
    During the COVID-19 pandemic, “patients lost all rights when they went in the hospital,” says Sen. Ron Johnson (R-Wis.) in the documentary “Making a Killing.” “They became prisoners.”
    In this episode, we sit down with Stella Paul, a medical writer who has been investigating what she describes as “deadly” hospital protocols during the pandemic—and the financial incentives behind them.
    “There were huge bonuses on what they were paid by the government if they used Remdesivir and if they ventilated—and both of those treatments are extremely dangerous,” Ms. Paul says.
    In this episode, she breaks down what she and others have uncovered.




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    Posts: 39424 | Location: SC Lowcountry/Cape Cod | Registered: November 22, 2002Reply With QuoteReport This Post
    Member
    posted Hide Post
    Michigan judge denies drug manufacturer's immunity in case of contaminated COVID-19 medication

    https://wwmt.com/news/local/mi...-covid-19-medication

    A Michigan judge has ruled for the first time that a drug manufacturer is not protected by the Public Readiness and Emergency Preparedness (PREP) Act in a case where a man suffered two strokes and a leg amputation after receiving a COVID-19 medication contaminated with glass particles.

    The PREP Act was declared by the U.S. Department of health and Human Services for emergency use, and shields manufacturers, administrators and distributors of vaccines from liability claims of loss caused by a drug.

    The case, filed by Ven Johnson Law on behalf of Dan Nowacki, focuses on how Nowacki suffered a stroke after receiving Remdesivir that was contaminated with glass particles.

    The drug was administered intravenously at St. Joseph Mercy Chelsea Hospital and is designed to combat COVID-19 symptoms.

    Two lots containing 55,000 vials of the drug were recalled after it was found they were contaminated with glass particles.

    In November 2021, Nowacki was admitted to St. Joseph Mercy Hospital in Chelsea with COVID-19.

    During his stay, he was administered five doses of Remdesivir and at least two of those doses belonged to the contaminated lot, the lawsuit states.



    Days later, he suffered a massive stroke and other serious complications.

    Nowacki developed hematomas and swelling on his face, thighs and arms.

    According to the lawsuit, around December 16, 2021, Nowacki suffered another stroke, which left him permanently bedridden and in need of 24/7 round-the-clock care.

    On July 12, 2023 and August 2, 2023, Judge Carol Kuhnke heard oral arguments from both Ven Johnson Law and the defendants as to whether the case should continue to trial.

    The defendants in the lawsuit was filed in Washtenaw County Circuit Court and listed Gilead Sciences, Inc., the drug manufacturer and St. Joseph Mercy Chelsea Hospital, Inc. as defendants.

    The judge ruled that Congress did not plan to extend the PREP Act immunity to a drug that substantially deviated from FDA approval and included glass particles.

    The defendants now must stand trial.


    _________________________
    "Sometimes I wonder whether the world is being run by smart people who are putting us on or by imbeciles who really mean it."
    Mark Twain
     
    Posts: 13380 | Registered: January 17, 2011Reply With QuoteReport This Post
    Partial dichotomy
    posted Hide Post
    ^^^ That is a huge breakthrough in the fight against BS pharmaceuticals!




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    Posts: 39424 | Location: SC Lowcountry/Cape Cod | Registered: November 22, 2002Reply With QuoteReport This Post
    Member
    Picture of Ironbutt
    posted Hide Post
    I got a call from the doctor's office this morning cancelling my wife's & my regular six month Medicare checkup tomorrow. It seems the entire nursing staff is out with covid.

    This is a small private practice, with only two doctors & three or four nurses. We've been going to them for over 25 years now. They're all nice, friendly people, but they got really weird about covid precautions. I'll bet they just weren't up to date on the latest covid booster. That's the problem.Smile


    ------------------------------------------------

    "It's hard to imagine a more stupid or dangerous way of making decisions, than by putting those decisions in the hands of people who pay no price for being wrong."
    Thomas Sowell
     
    Posts: 2048 | Location: PA | Registered: September 01, 2013Reply With QuoteReport This Post
    Lawyers, Guns
    and Money
    Picture of chellim1
    posted Hide Post
    Pfizer is going under the bus...

    Health Canada miraculously "found" SV40 promoter in Pfizer vials!
    So many governments are suddenly finding things that have been lost for years...
    Sasha Latypova
    Oct 19, 2023

    Please excuse typos, this is a very quick post with not much time for editing…

    based on the Epoch Times article:

    EXCLUSIVE: Health Canada Confirms Undisclosed Presence of DNA Sequence in Pfizer Shot "Health Canada has confirmed the presence of a Simian Virus 40 (SV40) DNA sequence in the Pfizer COVID-19 vaccine, which the manufacturer had not previously disclosed. There is debate among scientists with regards to the significance of the finding, with some saying it has the potential to cause cancer, and others saying it poses little to no threat. "Health Canada expects sponsors to identify any biologically functional DNA sequences within a plasmid (such as an SV40 enhancer) at the time of submission," the agency said in an email to The Epoch Times. "Although the full DNA sequence of the Pfizer plasmid was provided at the time of initial filing, the sponsor did not specifically identify the SV40 sequence." The regulator said that after scientists Kevin McKernan and Dr. Phillip J. Buckhaults publicly raised the presence of SV40 enhancers in the vaccines earlier this year, “it was possible for Health Canada to confirm the presence of the enhancer based on the plasmid DNA sequence submitted by Pfizer against the published SV40 enhancer sequence." Both scientists have made waves after discovering plasmid DNA in the mRNA COVID-19 injections, warning it could potentially alter the human genome. However, the two share different degrees of concern about the significance of an SV40 sequence—which is used as an enhancer to drive gene transcription during the vaccine manufacturing process—being present in the shots. Mr. McKernan, a former researcher and team leader for the Massachusetts Institute of Technology Human Genome Project, told The Epoch Times he suspects Pfizer didn’t disclose the presence of the DNA sequence due to the association of SV40 with polio vaccines. He said while there is no evidence the sequence is carcinogenic, he has concerns about its integration into the human genome. The polyomavirus Simian Virus 40, an oncogenic DNA virus, was previously removed from polio vaccines due to concerns about a link to cancers. Polio vaccines used in the late 1950s and early 1960s were found to be contaminated with SV40 as the virus was present in monkey kidney cells that were used to grow the vaccine. Mr. McKernan said while the full 5kb SV40 virus was present in the polio vaccines, the presence of SV40 promoters was still concerning due to the risk of them integrating into the human genomes near oncogenes, which are genes that have the potential to cause cancer Angus Dalgleish, professor of oncology at St. George's Hospital Medical School in London, recently wrote in The Conservative Woman about a higher incidence of cancers following COVID-19 vaccination seen by himself and his colleagues, including an “epidemic of explosive cancers” with multiple metastatic spread. He noted the potential “DNA plasmid and SV40 integration in promoting cancer development.” Dr. Lindsay questioned why Pfizer failed to disclose the SV40 promoter to regulators like the U.S. Food and Drug Administration, the European Medicines Agency, and Health Canada. "They hid them. So it's not just the fact that they're there, it's the fact that they were purposefully hidden from the regulators," she said. Pfizer did not respond to The Epoch Times' request for comment."

    This is after many have pointed out the Pfizer’s stock is heading into the toilet:

    What does this all mean? Have we won? Justice finally here? Bad bad Pfizer who lied and bought politicians is finally going to jail and we can get out of the “toxic quagmire of blame and retribution” and move on with our lives voting harder for the political candidates and sending money to Ukraine, Israel and WHO?

    A much better explanation of what is ongoing IMO is this:

    As part of “covid live military exercise” it was always planned that when deaths and injuries become so undeniable, that 98%+ Americans refuse the boosters (and technically become anti-vaxxers), and the truth about DOD deploying bioweapons on Americans with intent to kill and harm becomes sort of known, Pfizer will be “prosecuted” with much great publicity (to drown out the truth). Just like all previous “prosecutions”, there will be some sort of government investigation, millions spent on lawyers (gov and Pfizer), billions-trillions-gazzillions paid in fines TO THE GOVERNMENT, and maybe a few bucks will go to the victims, but don’t hold your breath. Pfizer will probably declare bankruptcy which will protect its shareholders. Criminals investigating themselves, when find themselves guilty, pay themselves. The end.

    https://sashalatypova.substack...r-is-going-under-the



    "Some things are apparent. Where government moves in, community retreats, civil society disintegrates and our ability to control our own destiny atrophies. The result is: families under siege; war in the streets; unapologetic expropriation of property; the precipitous decline of the rule of law; the rapid rise of corruption; the loss of civility and the triumph of deceit. The result is a debased, debauched culture which finds moral depravity entertaining and virtue contemptible."
    -- Justice Janice Rogers Brown

    "The United States government is the largest criminal enterprise on earth."
    -rduckwor
     
    Posts: 24772 | Location: St. Louis, MO | Registered: April 03, 2009Reply With QuoteReport This Post
    Lawyers, Guns
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    Picture of chellim1
    posted Hide Post
    And... based on the above...

    On Saturday, my friend, tech entrepreneur, and anti-vaccine activist Steve Kirsch set the internet on fire by excitedly and repeatedly tweeting that “you can now sue the vaccine makers:”

    https://twitter.com/stkirsch/s...820838564593745?s=20



    Steve’s enthusiasm ballooned after the Epoch Times ran a story Thursday headlined, EXCLUSIVE: Health Canada Confirms Undisclosed Presence of DNA Sequence in Pfizer Shot. In the story, the Canadian regulatory agency confirmed that an undisclosed SV40 gene can be found in the mRNA shots (more on that below). An agency spokesman told Epoch Times, "Although the full DNA sequence of the Pfizer plasmid was provided at the time of initial filing, the sponsor (Pfizer) did not specifically identify the SV40 sequence."

    Having a government regulatory agency confirm this issue is huge news. So Steve is technically correct. But legally, we’re still not quite all the way there yet. I’ll explain.

    Early this year, a heroic independent genetic researcher named Kevin McKernan discovered in the shots some DNA contamination (“plasmids”) in the form of E. coli and a harmful part of monkey DNA called the SV40 promoter gene. None of these things should have been in the jabs and it appears none were disclosed in Pfizer’s and Moderna’s EUA applications.

    Over the spring, summer, and into the fall, other researchers have confirmed Kevin’s original findings. In other words, other researchers are also finding plasmids and SV40 in the mRNA shots. And now, at least one government regulatory agency — Health Canada — has also confirmed the unexpected presence of SV40.

    So Steve is understandably excited because, if the contaminants (especially but not only the SV40 gene) were not, in fact, disclosed, then the products injected into people were not the same ones approved by the FDA, and therefore should not enjoy liability protection. There’s also another argument, that the jabs are “adulterated,” which gets you to the same spot.

    It may be enough that the products differ from what was on the EUA applications. But our scientists are still disagreeing over whether the contaminants pose any risk at all, or if they do, just how serious of a risk. What remains unclear to me, as a litigator, is who exactly has standing to sue a drug company for adulterated products absent clear evidence the contaminants caused the harms. I know, I know, but someone still must close that causation gap.

    And we still must prove that Pfizer’s EUA application in the United States was wrong. That is strongly suspected but not yet proven. The entire application is tens of thousands of pages.

    But. We are getting very, very close now. Stand by.

    https://www.coffeeandcovid.com...ack&utm_medium=email



    "Some things are apparent. Where government moves in, community retreats, civil society disintegrates and our ability to control our own destiny atrophies. The result is: families under siege; war in the streets; unapologetic expropriation of property; the precipitous decline of the rule of law; the rapid rise of corruption; the loss of civility and the triumph of deceit. The result is a debased, debauched culture which finds moral depravity entertaining and virtue contemptible."
    -- Justice Janice Rogers Brown

    "The United States government is the largest criminal enterprise on earth."
    -rduckwor
     
    Posts: 24772 | Location: St. Louis, MO | Registered: April 03, 2009Reply With QuoteReport This Post
    Wait, what?
    Picture of gearhounds
    posted Hide Post
    The number of people affected is mind boggling. If even a small fraction of them develop cancer (or reawaken cancer in remission) the number will be in the multi-millions. The big pharma culprits as well as the government officials complicit in the poisoning of the human race should all hang.




    “Remember to get vaccinated or a vaccinated person might get sick from a virus they got vaccinated against because you’re not vaccinated.” - author unknown
     
    Posts: 15937 | Location: Martinsburg WV | Registered: April 02, 2011Reply With QuoteReport This Post
    Knows too little
    about too much
    Picture of rduckwor
    posted Hide Post
    These "vaccines" are so full of junk DNA, RNA, and garbage that it is not even feasible that they would have been cleared for use had we all not been frightened to death by .gov.

    This may well become the largest fail in the history of mankind.

    RMD




    TL Davis: “The Second Amendment is special, not because it protects guns, but because its violation signals a government with the intention to oppress its people…”
    Remember: After the first one, the rest are free.
     
    Posts: 20412 | Location: L.A. - Lower Alabama | Registered: April 06, 2008Reply With QuoteReport This Post
    Lawyers, Guns
    and Money
    Picture of chellim1
    posted Hide Post
    quote:
    These "vaccines" are so full of junk DNA, RNA, and garbage...


    New Zealand is a Crime Scene: In one clinic, in one day 30 people were covid injected and all 30 have died

    https://www.2ndsmartestguyinth...7n3&utm_medium=email



    "Some things are apparent. Where government moves in, community retreats, civil society disintegrates and our ability to control our own destiny atrophies. The result is: families under siege; war in the streets; unapologetic expropriation of property; the precipitous decline of the rule of law; the rapid rise of corruption; the loss of civility and the triumph of deceit. The result is a debased, debauched culture which finds moral depravity entertaining and virtue contemptible."
    -- Justice Janice Rogers Brown

    "The United States government is the largest criminal enterprise on earth."
    -rduckwor
     
    Posts: 24772 | Location: St. Louis, MO | Registered: April 03, 2009Reply With QuoteReport This Post
    Still finding my way
    Picture of Ryanp225
    posted Hide Post
     
    Posts: 10851 | Registered: January 04, 2009Reply With QuoteReport This Post
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    posted Hide Post
    https://bpspubs.onlinelibrary....oi/10.1111/bph.16262



    Cardiac side effects of RNA-based SARS-CoV-2 vaccines: Hidden cardiotoxic effects of mRNA-1273 and BNT162b2 on ventricular myocyte function and structure

    First published: 12 October 2023

    Abstract

    Background and Purpose

    To protect against SARS-CoV-2 infection, the first mRNA-based vaccines, Spikevax (mRNA-1273, Moderna) and Comirnaty (BNT162b2, Pfizer/Biontech), were approved in 2020. The structure and assembly of the immunogen – in both cases, the SARS-CoV-2 spike (S) glycoprotein – are determined by a messenger RNA sequence that is translated by endogenous ribosomes. Cardiac side effects, which for the most part can be classified by their clinical symptoms as myo- and/or pericarditis, can be caused by both mRNA-1273 and BNT162b2.

    Experimental Approach

    As persuasive theories for the underlying pathomechanisms have yet to be developed, this study investigated the effect of mRNA-1273 and BNT162b2 on the function, structure, and viability of isolated adult rat cardiomyocytes over a 72 h period.

    Key Results

    In the first 24 h after application, both mRNA-1273 and BNT162b2 caused neither functional disturbances nor morphological abnormalities. After 48 h, expression of the encoded spike protein was detected in ventricular cardiomyocytes for both mRNAs. At this point in time, mRNA-1273 induced arrhythmic as well as completely irregular contractions associated with irregular as well as localized calcium transients, which provide indications of significant dysfunction of the cardiac ryanodine receptor (RyR2). In contrast, BNT162b2 increased cardiomyocyte contraction via significantly increased protein kinase A (PKA) activity at the cellular level.

    Conclusions and Implications

    Here we demonstrated for the first time, that in isolated cardiomyocytes, both mRNA-1273 and BNT162b2 induce specific dysfunctions that correlate pathophysiologically to cardiomyopathy. Both RyR2 impairment and sustained PKA activation may significantly increase the risk of acute cardiac events.


    _________________________
    "Sometimes I wonder whether the world is being run by smart people who are putting us on or by imbeciles who really mean it."
    Mark Twain
     
    Posts: 13380 | Registered: January 17, 2011Reply With QuoteReport This Post
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