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Savor the limelight |
Like everything else with COVID, the goal posts seem to be moving with these vaccines as well. I'm reading along the lines of X vaccine is 92% effective at preventing infection Y weeks after the second shot, but 65% effective after Z months at preventing symptomatic infection. The current vaccine narrative no longer seems to be about preventing the spread, but rather about how good they are at keeping you out of the hospital. My question then: are we just slowing down the inevatible with these vaccines? If a vaccine doesn't offer long term protection against infection, what good is it? Great, there's an 80% chance I won't have to go to the hospital if infected the first time, but what happens to the probability of being hospitalized with a 2nd, 3rd, 4th, etc. infection? If these vaccines are just slowing things down, does that just give the virus more chances to mutate into something worse? I'm having trouble thinking beyond my lack of sleep due to current sinus infection while trying figure out the best path forward for my family. | |||
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Tinker Sailor Soldier Pie |
Let's not forget, these "vaccines" do not at all do what was originally promised to us. So yes, the goalposts as you say keep moving. And our so-called betters all along are trying to convince everyone that this is all just part of the plan. But of course you need a booster shot. And then likely a yearly shot. You know, just like the flu! Oh, and here. You need to take these two pills daily in conjunction with the vaccines in perpetuity. And yes, you have to keep wearing the mask. Obviously. Why would you even ask? ~Alan Acta Non Verba NRA Life Member (Patron) God, Family, Guns, Country Men will fight and die to protect women... because women protect everything else. ~Andrew Klavan | |||
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Wait, what? |
Loosing a mostly untested unknown vaccine on the world was bad enough. Getting it once (twice with a dual shot) carries unknown consequences as far as I'm concerned. Now throw in the "booster". THEN consider the possibility that with every variant, there will likely be a push for booster after booster after booster. Nobody knows what or if there will be any long term concerns over these shots. Why? for a virus that has less impact every day and an overall mortality of under 1%. It makes no sense. “Remember to get vaccinated or a vaccinated person might get sick from a virus they got vaccinated against because you’re not vaccinated.” - author unknown | |||
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Member |
Pretty much states why I won't get one. My biggest thing is the push and the rush that got the vaccine out to the public. Long term tests? It's only been available since December 2020 I think. Emergency authorized only. A few months later, approved. "This should help those that were hesitant to get the vaccine by having full FDA approval". It did the opposite for me personally. I'd rather be hated for who I am than loved for who I'm not. | |||
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Member |
This is a huge concern of forcing the vaccine on every human, but is rarely discussed. (STUDY) Why so many vaccinated people are getting sick: Antibody Dependent Enhancement (ADE) https://sharylattkisson.com/20...le-are-getting-sick/ According to studies: https://www.nature.com/articles/s41564-020-00789-5 ADE can make vaccinated people more susceptible to serious infection from the virus "ADE may be a concern" for those who have been vaccinated for Covid-19 With ADE, after people get vaccinated for an initial virus, infection by a subsequent variant or strain of the virus can result in "increased viral replication and more severe disease, leading to major safety risks" ADE can also "occur when neutralizing antibodies (which bind the virus and stop it from causing infection) are present at low enough levels that they don't protect against infection. Instead, they can form immune complexes with viral particles, which in turn leads to worse illness" This concern was initially described by some scientists who were subsequently banned from media platforms that incorrectly claimed the scientists were disseminating disinformation Study scientists suggest the answer is to create a new vaccine In a new study in the Journal of Infection, scientists explain one likely reason why so many vaccinated people are getting sick: a dangerous phenomenon called Antibody Dependent Enhancement or ADE. Despite the fact that multiple medical authorities predicted, told us, and hoped, ADE would not impact Covid-19 vaccines, data from the study indicates it has done just that. According to the new study, data suggests that the Covid-19 vaccines originally appeared to provide an overall benefit in fighting the virus. However, when it comes to one of the newer iterations of Covid, the Delta variant, the vaccines appear to facilitate infection displaying "a strikingly increased affinity" for the virus' trademark spike protein. The scientists conclude that "ADE may be a concern" for those who have been vaccinated for Covid-19. Read the study here. https://www.journalofinfection...(21)00392-3/fulltext According to scientific study, the ADE risk was well known prior to the Covid-19 vaccines being allowed on the market. "One potential hurdle for antibody-based vaccines and therapeutics is the risk of exacerbating COVID-19 severity via antibody-dependent enhancement (ADE)," explained a study in Nature. "ADE can increase the severity of multiple viral infections, including other respiratory viruses such as respiratory syncytial virus (RSV) and measles." Scientists say that with ADE, after people get vaccinated for an initial virus, infection by a subsequent variant or strain of the virus can result in "increased viral replication and more severe disease, leading to major safety risks." "Non-neutralizing antibodies generated by past infection or vaccination fail to shut down the pathogen upon re-exposure. Instead, they act as a gateway by allowing the virus to gain entry and replicate in cells that are usually off limits... That, in turn, can lead to wider dissemination of illness, and over-reactive immune responses that cause more severe illness," according to scientists. An article in MedPage (prior to the new study) dismissed concerns about ADE, but noted it "can also occur when neutralizing antibodies (which bind the virus and stop it from causing infection) are present at low enough levels that they don't protect against infection. Instead, they can form immune complexes with viral particles, which in turn leads to worse illness." On the other hand, most scientific studies on this topic say those who have recovered from Covid-19 have natural immunity that does not display the same problem, and appears to be superior to that, so far, of that provided by the vaccines. Nonetheless, the Centers for Disease Control (CDC) and many public health officials are pressing for more people to get vaccinated, including those who have been previously-infected with Covid. (Numerous studies suggest there is no benefit to recovered patients getting vaccinated.) The health officials state that the vaccinated patients who are getting Covid are getting milder forms than they would have if they had not been vaccinated. However, that is a case-by-case assumption and is impossible to prove. In Israel, health officials say that only 1% among Covid infections in the latest wave are among those previously infected with Covid. The other 99% are among unvaccinated and not previously-infected, and among fully-vaccinated. Covid-19 Natural Immunity: The Definitive Summary Covid-19 Vaccine Concerns Summary Covid-19 Vaccine Analysis: Common Adverse Events Covid-19 Origins: Separating Rumor from Fact (WATCH) Report a Possible Vaccine Adverse Event, According to the new study, the solution to the current ADE problem is to invent a new, updated version of the vaccine. Children's Hospital of Philadelphia (which accepts funding from the vaccine industry) reports the following about ADE: A major goal of antibodies is to bind to the pathogen and prevent it from infecting, or entering, a cell. Antibodies that prevent entry into cells are called neutralizing antibodies. Many vaccines work by inducing neutralizing antibodies. However, not all antibody responses are created equal. Sometimes antibodies do not prevent cell entry and, on rare occasions, they may actually increase the ability of a virus to enter cells and cause a worsening of disease through a mechanism called antibody-dependent enhancement (ADE). What is ADE? ADE occurs when the antibodies generated during an immune response recognize and bind to a pathogen, but they are unable to prevent infection. Instead, these antibodies act as a “Trojan horse,” allowing the pathogen to get into cells and exacerbate the immune response. Is ADE caused by vaccines? On a few occasions ADE has resulted from vaccination: Respiratory syncytial virus (RSV) — RSV is a virus that commonly causes pneumonia in children. A vaccine was made by growing RSV, purifying it, and inactivating it with the chemical formaldehyde. In clinical trials, children who were given the vaccine were more likely to develop or die from pneumonia after infection with RSV. As a result of this finding, the vaccine trials stopped, and the vaccine was never submitted for approval or released to the public. Measles — An early version of measles vaccine was made by inactivating measles virus using formaldehyde. Children who were vaccinated and later became infected with measles in the community developed high fevers, unusual rash, and an atypical form of pneumonia. Upon seeing these results, the vaccine was withdrawn from use, and those who received this version of the vaccine were recommended to be vaccinated again using the live, weakened measles vaccine, which does not cause ADE and is still in use today. A more recent example of ADE following vaccination comes from dengue virus: Dengue virus — In 2016, a dengue virus vaccine was designed to protect against all four serotypes of the virus. The hope was that by inducing immune responses to all four serotypes at once, the vaccine could circumvent the issues related to ADE following disease with dengue virus. The vaccine was given to 800,000 children in the Philippines. Fourteen vaccinated children died after encountering dengue virus in the community. It is hypothesized that the children developed antibody responses that were not capable of neutralizing the natural virus circulating in the community. As such, the vaccine was recommended only for children greater than 9 years of age who had already been exposed to the virus. Should I be concerned that my child will develop ADE after receiving a vaccination? Today’s routinely recommended vaccines do not cause ADE. If they did, like those described above, they would be removed from use. Phase III clinical trials are designed to uncover frequent or severe side effects before a vaccine is approved for use. Read more on ADE here. Read more from the new study below: Antibody dependent enhancement (ADE) of infection is a safety concern for vaccine strategies. In a recent publication, Li et al. (Cell 184 :1-17, 2021) have reported that infection-enhancing antibodies directed against the N-terminal domain (NTD) of the SARS-CoV-2 spike protein facilitate virus infection in vitro, but not in vivo. However, this study was performed with the original Wuhan/D614G strain. Since the Covid-19 pandemic is now dominated with Delta variants, we analyzed the interaction of facilitating antibodies with the NTD of these variants. Using molecular modelling approaches, we show that enhancing antibodies have a higher affinity for Delta variants than for Wuhan/D614G NTDs. We show that enhancing antibodies reinforce the binding of the spike trimer to the host cell membrane by clamping the NTD to lipid raft microdomains. This stabilizing mechanism may facilitate the conformational change that induces the demasking of the receptor binding domain. As the NTD is also targeted by neutralizing antibodies, our data suggest that the balance between neutralizing and facilitating antibodies in vaccinated individuals is in favor of neutralization for the original Wuhan/D614G strain. However, in the case of the Delta variant, neutralizing antibodies have a decreased affinity for the spike protein, whereas facilitating antibodies display a strikingly increased affinity. Thus, ADE may be a concern for people receiving vaccines based on the original Wuhan strain spike sequence (either mRNA or viral vectors). Under these circumstances, second generation vaccines with spike protein formulations lacking structurally-conserved ADE-related epitopes should be considered.The aim of the present study was to evaluate the recognition of SARS-CoV-2 Delta variants by infection enhancing antibodies directed against the NTD. The antibody studied is 1054 (pdb file #7LAB) which has been isolated from a symptomatic Covid-19 patient1. Molecular modelling simulations were performed as previously described2. Two currently circulating Delta variants were investigated, with the following mutational patterns in the NTD : - G142D/E154K (B.1.617.1) - T19R/E156G/del157/del158/A222V (B.1.617.2) Each mutational pattern was introduced in the original Wuhan/D614G strain, submitted to energy minimization, and then tested for antibody binding. The energy of interaction (ΔG) of the reference pdb file #7LAB (Wuhan/D614G strain) in the NTD region was estimated to -229 kJ/mol−1. In the case of Delta variants, the energy of interaction was raised to -272 kJ.mol−1(B.1.617.1) and -246 kJ.mol−1 (B.1.617.2). Thus, these infection enhancing antibodies not only still recognize Delta variants but even display a higher affinity for those variants than for the original SARS-CoV-2 strain.The global structure of the trimeric spike of the B.1.617.1 variant in the cell-facing view is shown in Figure 1A. As expected, the facilitating antibody bound to the NTD (in green) is located behind the contact surface so that it does not interfere with virus-cell attachment. Indeed, a preformed antibody-NTD complex could perfectly bind to the host cell membrane. The interaction between the NTD and a lipid raft is shown in Figure 1B, and a whole raft-spike-antibody complex in Figure 1C. Interestingly, a small part of the antibody was found to interact with the lipid raft, as further illustrated in Figures 1D-E. More precisely, two distinct loops of the heavy chain of the antibody encompassing amino acid residues 28-31 and 72-74, stabilize the complex through a direct interaction with the edge of lipid raft (Figure 1F). Overall, the energy of interaction of the NTD-raft complex was raised from -399 kJ.mol−1 in absence of the antibody to -457 kJ.mol−1 with the antibody. By clamping the NTD and the lipid raft, the antibody reinforces the attachment of the spike protein to the cell surface and thus facilitates the conformational change of the RBD which is the next step of the virus infection process2. _________________________ "Sometimes I wonder whether the world is being run by smart people who are putting us on or by imbeciles who really mean it." Mark Twain | |||
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Lawyers, Guns and Money |
Studies, more and more of them, are suggesting that the vaccine-induced spike itself is dangerous to human tissue. A December 2021 study concluded, “The potential implications of S-protein amyloidogenesis in COVID-19 disease associated pathogenesis and consequences following S-protein based vaccines should be addressed in understanding … vaccine side effects.” A more recent study (April 15th) asserts the mRNA-induced spikes are themselves toxic. The authors wrote: In this paper, we present evidence that vaccination induces a profound impairment in type I interferon signaling, which has diverse adverse consequences to human health. Immune cells that have taken up the vaccine nanoparticles release into circulation large numbers of exosomes containing spike protein along with critical microRNAs that induce a signaling response in recipient cells at distant sites. We also identify potential profound disturbances in regulatory control of protein synthesis and cancer surveillance. These disturbances potentially have a causal link to neurodegenerative disease, myocarditis, immune thrombocytopenia, Bell’s palsy, liver disease, impaired adaptive immunity, impaired DNA damage response and tumorigenesis. Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs https://www.sciencedirect.com/...ii/S027869152200206X "Some things are apparent. Where government moves in, community retreats, civil society disintegrates and our ability to control our own destiny atrophies. The result is: families under siege; war in the streets; unapologetic expropriation of property; the precipitous decline of the rule of law; the rapid rise of corruption; the loss of civility and the triumph of deceit. The result is a debased, debauched culture which finds moral depravity entertaining and virtue contemptible." -- Justice Janice Rogers Brown "The United States government is the largest criminal enterprise on earth." -rduckwor | |||
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Wait, what? |
We’re only seeing the tip of the iceberg on the long term adverse effects I fear. “Remember to get vaccinated or a vaccinated person might get sick from a virus they got vaccinated against because you’re not vaccinated.” - author unknown | |||
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Tinker Sailor Soldier Pie |
Superpower. What a sick joke. More like supervillian. ~Alan Acta Non Verba NRA Life Member (Patron) God, Family, Guns, Country Men will fight and die to protect women... because women protect everything else. ~Andrew Klavan | |||
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Ammoholic |
This post did not age well. Jesse Sic Semper Tyrannis | |||
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Member |
It still kills me to think that we had members on this very board CHASTISING...CHASTISING!...those of us that chose Medical and Religious Autonomy and Informed Consent and didn't get the jab(s)(s)(s)(s). JSMH... "If you’re a leader, you lead the way. Not just on the easy ones; you take the tough ones too…” – MAJ Richard D. Winters (1918-2011), E Company, 2nd Battalion, 506th Parachute Infantry Regiment, 101st Airborne "Woe to those who call evil good, and good evil... Therefore, as tongues of fire lick up straw and as dry grass sinks down in the flames, so their roots will decay and their flowers blow away like dust; for they have rejected the law of the Lord Almighty and spurned the word of the Holy One of Israel." - Isaiah 5:20,24 | |||
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Fire begets Fire |
Does anyone think getting the wuflu i.e. the China “vaccine” natural immunity is less problematic? Where do you think the spike proteins for the antigen came from? "Pacifism is a shifty doctrine under which a man accepts the benefits of the social group without being willing to pay - and claims a halo for his dishonesty." ~Robert A. Heinlein | |||
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Member |
I have learned over the last two years that there are VERY FEW people with the ability to think critically and apply common sense, coupled with VERY MANY people easily cowed by media/government induced fear. These people truly believed, to their very core, that they were taking a miracle drug that cured some kind of illness that was apparently worse than cancer, AIDS and polio combined into one, and that those people who didn't take their miracle drug were enemies of humanity, worthy of scorn. | |||
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Member |
And many of them have since gone radio silent. One of their favorite sayings was “trust the science”. Uhhh, I hate to break it to them but when the general public is being duped and used as beta testers, that isn’t science. ——————————————— The fool hath said in his heart, There is no God. Psalm 14:1 | |||
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