They are the same for me- whatever I CC is also the HD.

Recently my nightstand gun has become a very quiet carbine in 300 BO.

Sig P226 with a light on the bedside table for the most part...but usually a Smith M60 3" or a Sig p365 on the belt for trips to town. We live on a farm and I've always got a hand gun strapped on...what ever interests me that morning...so I'm used to different operating systems...but all, ALL, are carried in the old FBI 3-4 o'clock position in an OWB of my own making. YMMv, Rod

Not similar in the least bit.

CCW- small striker fired gun (G43)
Nightstand- big 2011 gun (Staccato P)

It’s the same gun. Sometimes is in a holster, some times it’s not.

I scratched my head a bit, while thinking, and replied “Totally Different,” but it is actually a bit more complicated. My carry gun, for the day, would normally be stashed nearby, but, not on the nightstand. If awakened by a bump in the night, or similar, I am going to reach for the Benelli M2, which was my duty shotgun during the final two years of my policin’ career.

Similar. Walther PPS vs PPQ

Same gun: Beretta 92g LTT Centurion right now.

Similar in that they are striker fired. P320 bedside and either a P365 or PPQ for carry.

I don't know how they could be the same gun. It seems, to me, that you'd be making a rather large compromise in either use-case, if they were. My bedside gun is a MK25 with a light/laser and silencer. My carry gun is a Taurus TCP, with an extra mag. If I am outside the walls of the house, I have the TCP; I don't care to carry a larger gun, as much as I carry that gun. Obviously, I'd be doing my family a disservice, if that was my bedside gun. The MK25 comes with me to work 5/7 days of the week, and lives, silencer removed, in my backpack, typically at arms reach. A carbine is in the trunk of the vehicle, less than 50m away. Considering those typical circumstances of mine, I feel (almost) adequately equipped with the TCP. I admittedly make compromises, in carrying that gun, in the name of comfort. There's no way I could be as equipped during the day, as I am at night, and I am not going to short-change myself at night, in the name of using the same gun for everything. I practice with both, and the little TCP is actually good-shooting little gun.

For me = I have several handguns around my child free home = SIG P365XL, Glock 43X, Springfield Hellcat OSP, & two M&P Shields
Also have a few full size pistols = Glock 19X & S&W SD9
All are 9mm polymer framed striker fired handguns lately
Youngest Son is 31...

Very VERY different. Currently my EDC is a Kel-Tec P32 in my right front pants pocket. My nightstand gun is a Glock 21 with a CT green laser.

When I'm on my bicycle, I have a fanny back holster with a Beretta APX/Nano hybrid or a Glock G42.