Born and raised Pittsburgher here. I say Pittsburgher as pretty much all who live in the surrounding suburban area call themselves Pittsburghers but the city proper itself is kind of small. I live just outside of the city but work in Oakland, which is basically a campus of the University of Pittsburgh and multiple UPMC hospitals.

Have you ever been to Philly and stood on Broad Street and looked both ways, and the street just went on and on for blocks and blocks? Yeah, not here. There's not a single straight, level or non-under/overpass road in the whole area. Part of the charm I guess. But you can see tall buildings that you will take two hours to get to. Oh, and tunnels, yeah tunnels. Great as long as you are not claustrophobic. Or in a hurry to get to one of those buildings that you can see but can't get to.

As far as Primanti's goes, the sandwiches are very tasty, but a comment on the Kielbasa they use. They used to use a typical Pittsburgh deli/butcher hunk that they would split and grill for the sandwich, but a couple of years ago they switched to Boski brand which really sucks, to me.

But seriously, relatively safe but even in some of the nightlife areas they are getting sketchy like any other place. I wouldn't let that stop me from venturing out to explore, just as others mentioned situational awareness is your friend.

In addition to many of the great suggestions made, if you lean toward museum type attractions, there are many great ones, I would add in the Oakland/Pitt campus area the Nationality rooms at the Cathedral of Learning (Can't miss it, Gothic stone building that towers over Oakland) and from there a short walk to the Phipps Conservatory with seasonal floral displays and shows; Carnegie Museum of Natural History and the Scaife Art Museum. Also an often overlooked museum in the Soldier's and Sailor's Memorial across the street from the Cathedral of Learning. Used to be observation decks open way up in the building but have been closed mostly since 9/11. And there is a Primanti's right in Oakland!

Side note, I went to Duquesne University just down the road a bit toward the city, but a frat brother worked at the Oakland Primanti's when it opened. We would do the typical Oakland bar crawl ending up there at 2:30am and he'd feed our drunken asses.

If you are a baseball fan, there is still a short portion of the brick left field wall from Forbes Field still standing where Bill Mazeroski hit the famous 9th inning walk off to win the 1960 World Series. This is just one small area of Pittsburgh, tons of interesting other neighborhoods, Warhol Museum, the North Shore with the ballparks today, the Science Center near the casino on the river, if you get bored here for a week, its your fault!

I am a fan of the walking food tours. You get to experience so many things you may miss out on going to a single restaurant.

I have no personal experience but you check out some tours here https://www.burghfoodtour.com/

Hill Street Blues was based on an anonymous, fictional Midwestern or Northeastern U.S. city, a blend of Chicago, Buffalo, and Pittsburgh, though the series was primarily filmed in and around Los Angeles. The setting was designed to be a generic, gritty urban environment rather than a specific real-world location.