Statins vs. supplements: New study finds one is 'vastly superior' to cut cholesterol
Are 190 participants really enough to draw any conclusions ?
November 07, 2022, 01:18 PM
jhe888
quote:
Originally posted by c1steve: What about having a proper diet and exercise somewhat? You would need NO meds. Better to fix the underlying problem, than cover it up with meds.
Well, perhaps, but some people might have problems even with perfect diet.
And even more people won't comply. They like steak and ice cream. So drugs are useful for them.
The fish is mute, expressionless. The fish doesn't think because the fish knows everything.
November 07, 2022, 02:00 PM
SigSentry
quote:
Originally posted by smschulz: One of the things I hate about statins besides the side effects it that they don't decrease the LDL that does the real damage> small particle LDL. Large LDL particles are relatively harmless even if they contain more cholesterol. So focusing simply on LDL is insufficient.
Recently got my annual bloodwork back. It seems concerning that the normal reference range for LDL is 0 to 99. I'm pretty sure if your ldl is zero, that's NOT normal. My vldl (remnant) was 18 which is a good indication of how long LDL is sitting around getting glycated. Yes, someday a nmr particle size/count, pattern A or B etc. will be standard along with a fasting insulin.
Originally posted by mike28w: I never understand these types of discussions .... If you don't trust your doctor or the drugs, simply quit going to him and quit taking the drug. It's that simple. Life's a gamble and whether you realize it or not, you are gambling with your life everyday. " You pays your money and you takes your chances"... You could get run over by a truck tomorrow....
As for me, I go to the doc and take the pills... (And I can still get run over by a truck as I step out into the parking lot.)
I halfway trusted one or two doctors until they all pushed the stupid ass Rona vax on everyone. I’m out.
28 days I bet they spent more time writing the report than the patients spent in the trial. Way too short for a drug people go on for years or decades.
quote:
Originally posted by TomV: Are 190 participants really enough to draw any conclusions ?
+1
28 day, 190 participant “study” is half-assed for a drug has been on the market long enough to have a generic. To be even more blunt, it’s been out long enough to have multiple year with thousands of patients.
Ego is the anesthesia that deadens the pain of stupidity
DISCLAIMER: These are the author's own personal views and do not represent the views of the author's employer.
November 07, 2022, 02:18 PM
ZSMICHAEL
MOst of the studies these days are meta analysis. To its credit this is not one of those. I guess some of you trust the TV hucksters who are shilling all kinds of worthless shit. For example PREVAGEN. What a crock. No scientific studies, but it is made from Jellyfish to so it is good to go. Another product is T boosters. I mean WTF. You can get the real deal from your endocrinologist but you trust some washed up athlete. The latest crock is psychedelic drugs, touted by AAron Rodgers. Boy is he having a great year!
November 07, 2022, 03:49 PM
smschulz
quote:
Originally posted by SigSentry:
Recently got my annual bloodwork back. It seems concerning that the normal reference range for LDL is 0 to 99. I'm pretty sure if your ldl is zero, that's NOT normal. My vldl (remnant) was 18 which is a good indication of how long LDL is sitting around getting glycated. Yes, someday a nmr particle size/count, pattern A or B etc. will be standard along with a fasting insulin.
The Pattern A or B is significant data. Pattern A = Large Pattern B = Small
A lot of factors with Lipids.
November 07, 2022, 05:38 PM
2PAK
Prevagen is the king of BS. My mother, before she passed, had dementia and was convinced Prevagen was the path back to normalcy. My step father would buy and give her one a day in order to calm her down otherwise she would talk about all day long. I can imagine the sales of Prevagen are epic as some seniors will buy anything William Shatner, Tom Sellack or some company hawking a pill made from a Jellyfish to improve memory will try and sell.
November 07, 2022, 06:58 PM
signewt
is anyone familiar with a newish med called "Evolocumab".
My cardiologist today suggested this was very effective for cholesterol, especially where statins can't be tolerated.
I've got some basic reading to do on this.
November 07, 2022, 07:43 PM
nhtagmember
After what pharma has done to us over the last 30 months, the lies, the deceptions and the misdirection it’s clear to me at least that nothing that comes out of pharma can be considered truthful unless it’s validated by someone else.
Pharma isn’t interested in health, they’re simply interested in their cash flow and how to separate you from your hard earned money - no matter what it may do to you in the end.
November 07, 2022, 07:48 PM
ZSMICHAEL
quote:
Evolocumab
^^^^^^^^^^^^ It is a human monoclonal antibody. Expensive. Insurance will probably want you to demonstrate failure on statins.
November 07, 2022, 07:59 PM
barndg00
By the way, if you read the methodology of the study, they used 5mg dose of Crestor - literally the lowest dose they make. And it beat the pants off the homeopathic crap.
November 07, 2022, 09:27 PM
SigSentry
quote:
Originally posted by smschulz:
quote:
Originally posted by SigSentry:
Recently got my annual bloodwork back. It seems concerning that the normal reference range for LDL is 0 to 99. I'm pretty sure if your ldl is zero, that's NOT normal. My vldl (remnant) was 18 which is a good indication of how long LDL is sitting around getting glycated. Yes, someday a nmr particle size/count, pattern A or B etc. will be standard along with a fasting insulin.
The Pattern A or B is significant data. Pattern A = Large Pattern B = Small
A lot of factors with Lipids.
A good primer. Good/bad cholesterol is old news.
November 07, 2022, 09:30 PM
wrightd
quote:
Originally posted by Anush: Statins also may cause Type 2 Diabetis in some people. I was taking Simvastatin & my A1C increased every year until I stopped. My A1C dropped 2 points immediately. Some permanent damage had already occured.
Like from 8 to 6, or 9 to 7 ? Like that ?
Lover of the US Constitution Wile E. Coyote School of DIY Disaster
November 07, 2022, 09:34 PM
wrightd
quote:
Originally posted by jhe888:
quote:
Originally posted by c1steve: What about having a proper diet and exercise somewhat? You would need NO meds. Better to fix the underlying problem, than cover it up with meds.
Well, perhaps, but some people might have problems even with perfect diet.
And even more people won't comply. They like steak and ice cream. So drugs are useful for them.
My Primary doc told me bad cholesterol is mostly genetic, other things being equal of course. I had a friend like that, he ate healthy, but his genetic cholesterol was off the scale. He took strong anti-cholesterol meds from his doc, from what I understand, to just stay alive. He's the funniest man I know, he was born with a natural funny bone, he can make you laugh so hard you can't breathe. Maybe that's why he's still going strong.
Lover of the US Constitution Wile E. Coyote School of DIY Disaster
November 08, 2022, 08:32 AM
Keystoner
quote:
Originally posted by wrightd: He's the funniest man I know, he was born with a natural funny bone, he can make you laugh so hard you can't breathe. Maybe that's why he's still going strong.
I heard this on morning radio years ago, and I believe it: those belly-aching laughs add time to your life, even if you fake it. So the morning host started faking a belly-aching laugh and it was so contagious that everyone, including me, was having a great laugh.
Year V
November 09, 2022, 09:24 AM
smschulz
This is a very informative and easy to understand video on Cholesterol including testing and numbers. Even though it is long it is easy to watch and puts the proper perspective that so many Doctors fail to explain and simply just prescribe statins.
November 09, 2022, 04:43 PM
flashguy
I've been taking Crestor (rosuvastatin) for a long time, as prescribed by my doctor. I like it because it seems to be the only statin that allows some ingestion of grapefruit, one of my favorite fruits (Red).
flashguy
Texan by choice, not accident of birth
November 09, 2022, 10:55 PM
signewt
quote:
Originally posted by ZSMICHAEL:
quote:
Evolocumab
^^^^^^^^^^^^ It is a human monoclonal antibody. Expensive.
AKA "Repatha" been reading up on it. Over $700/month/long term.
Doing a bit of study to learn what the cardiologist & internist have to teach about these meds. Side effects reported seems rather risky as well.
I bet they spent more time writing the report than the patients spent in the trial. Way too short for a drug people go on for years or decades.