quote:

Originally posted by kz1000:
You'll wanna take it again 2 hours later...

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The raw material for the recalled heparin batches was processed in China from pig's intestines by the American pharmaceutical firm Scientific Protein Laboratories.[3][4][5] The U.S. Food and Drug Administration was quoted as stating that at least 81 deaths were believed to be linked to a raw heparin ingredient imported from the People's Republic of China, and that they had also received 785 reports of serious injuries associated with the drug’s use.[6] According to The New York Times, "problems with heparin reported to the agency include difficulty breathing, nausea, vomiting, excessive sweating and rapidly falling blood pressure that in some cases led to life-threatening shock."[4]

Upon investigation of these adverse events by the FDA, academic institutions, and the involved pharmaceutical companies, the contaminant was identified as an "over-sulfated" derivative of chondroitin sulfate, a closely related substance obtained from mammal or fish cartilage and often used as a treatment for arthritis.[3][7] Since over-sulfated chondroitin is not a naturally occurring molecule, costs a fraction of true heparin starting material, and mimics the in-vitro properties of heparin, the counterfeit was almost certainly intentional as opposed to an accidental lapse in manufacturing.[8] The raw heparin batches were found to have been cut from 2–60% with the counterfeit substance, and motivation for the adulteration was attributed to a combination of cost effectiveness and a shortage of suitable pigs in China.

When the FDA conducted an inspection of Baxter's Chinese Heparin supplier, it found serious deficiencies at the facility which the FDA detailed in a warning letter.[9][10]

This example once again demonstrated the consequences of a company not following basic Good Manufacturing Practices (GMPs). As detailed in the Warning Letter, the company failed to monitor changes in the impurity profile of incoming heparin active raw material, adequately investigate out-of-specification results, document actual processing steps in batch records, validate all critical steps in the process, qualify all suppliers, and use valid methods to test products.

The FDA has stated that it does not have the funds nor bear the responsibility to inspect on a regular basis overseas upstream processors of finished active pharmaceutical ingredients such as heparin. However, according to the internationally harmonized guideline, ICH Q7, API manufacturers are fully responsible for qualifying their suppliers through on-site audits, testing, and regular communications. This ongoing responsibility is essential to ensure supply chain security, drug quality and drug safety, These basic commitments to the pharmaceutical consumer can only be ensured by adherence to Good Manufacturing Practice and Good Distribution Practice

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Originally posted by Oz_Shadow:
I do not trust China.

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Originally posted by rusbro:

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Originally posted by Oz_Shadow:
I do not trust China.

It's got tiger tusks and cow testicles in it. Very potent stuff.

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Baxter's Chinese Heparin

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He who fights with monsters might take care lest he thereby become a monster.

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Originally posted by 12131:
Chinese med's side effect: impotence.

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Originally posted by signewt:
"I don't know why we would trust our meds to Chinese production."

this remains an open question in many other critical products as well

'simple greed' does not seem to be an adequate response

Years ago (around 2010) my anxieties were tweaked when reading story of outsourced aircraft turbine blades.

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Originally posted by Jimbo54:
Oh hell no!. BP medication is cheap, cheap. Why would anyone buy it from China.

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Originally posted by PD:

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Originally posted by Jimbo54:
Oh hell no!. BP medication is cheap, cheap. Why would anyone buy it from China.

Because you don’t know. Do you ask your pharmacist the country of origin of every refill you get? The doctor writes an Rx and the pharmacist fills it.

I went to RiteAide yesterday with my empty Valsartan bottle and the guy just shook his head. Said he’ll call my doc for a replacement and he did confirm it was a Chinese problem.

Fuck the FDA, too! The FDA release does not mention Chinese production.

quote:

Originally posted by kz1000:
You'll wanna take it again 2 hours later...