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Yeah, inter-species gene splicing. What could possibly go wrong?

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Originally posted by jhe888:

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Originally posted by Nickelsig229:
Don't rodent teeth never stop growing?

Imagine if you could splice into that gene, where human teeth never stop growing. That would solve alot of problems.

I mean, chocolate flavored log, I might could naw on two or three a night

And we'd be gnawing on a log constantly.

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Abstract

Uterine sensitization-associated gene-1 (USAG-1) deficiency leads to enhanced bone morphogenetic protein (BMP) signaling, leading to supernumerary teeth formation. Furthermore, antibodies interfering with binding of USAG-1 to BMP, but not lipoprotein receptor-related protein 5/6 (LRP5/6), accelerate tooth development. Since USAG-1 inhibits Wnt and BMP signals, the essential factors for tooth development, via direct binding to BMP and Wnt coreceptor LRP5/6, we hypothesized that USAG-1 plays key regulatory roles in suppressing tooth development. However, the involvement of USAG-1 in various types of congenital tooth agenesis remains unknown. Here, we show that blocking USAG-1 function through USAG-1 knockout or anti-USAG-1 antibody administration relieves congenital tooth agenesis caused by various genetic abnormalities in mice. Our results demonstrate that USAG-1 controls the number of teeth by inhibiting development of potential tooth germs in wild-type or mutant mice missing teeth. Anti-USAG-1 antibody administration is, therefore, a promising approach for tooth regeneration therapy.

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Originally posted by Expert308:
Yeah, inter-species gene splicing. What could possibly go wrong?