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Despite being the closest relatives of domestic cattle native to North America, bison were never domesticated by Native Americans. Later attempts of domestication by Europeans prior to the 20th century met with limited success. Bison were described as having a "wild and ungovernable temper";[41] they can jump close to 6 ft (1.8 m) vertically,[42] and run 35–40 mph (56–64 km/h) when agitated. This agility and speed, combined with their great size and weight, makes bison herds difficult to confine, as they can easily escape or destroy most fencing systems, including most razor wire.

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Dangers to humans
Bison are among the most dangerous animals encountered by visitors to the various U.S. and Canadian national parks and will attack humans if provoked. They appear slow because of their lethargic movements, but can easily outrun humans; bison have been observed running as fast as 40 mph (64 km/h).
Between 1980 and 1999, more than three times as many people in Yellowstone National Park were injured by bison than by bears. During this period, bison charged and injured 79 people, with injuries ranging from goring puncture wounds and broken bones to bruises and abrasions. Bears injured 24 people during the same time. Three people died from the injuries inflicted—one person by bison in 1983, and two people by bears in 1984 and 1986