Ive never had an issue with a suppressed P22x series gun while running a can. They are my preferred host as Ive not had to run anything different than stock though I also enjoy a suppressed Steyr M9A1. G19 also works well. I think the P22xs do give very good results on a meter for what its worth if you like a more scientific approach.

I did have problems running a VP9 Tactical with a can and the same ammo types I run through the above.